UDP-glucose 4-epimerase
（重定向自UDP galactose epimerase）
![](/Images/godic/202502/18/Human_GALE_bound_to_NADH_and_UDP-glucose2441.png")
![](/Images/godic/202502/18/Human_GALE_bound_to_NAD+_and_UDP-GlcNAc2441.png")
![Intermediates and enzymes in the Leloir pathway of galactose metabolism.[1]](/Images/godic/202502/18/Leloir_pathway2441.png")
The enzyme UDP-glucose 4-epimerase (EC5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.