Tyrosinemia type II
（重定向自Type II tyrosinemia）
![](/Images/godic/202502/18/L-tyrosine-skeletal4026.png")
![Pathophysiology of metabolic disorders of tyrosine, resulting in elevated levels of tyrosine in blood.](/Images/godic/202502/18/Pathophysiology_of_metabolic_disorders_of_phenylalanine_and_tyrosine4026.png")
Tyrosinemia type II (Oculocutaneous tyrosinemia, Richner-Hanhart syndrome) is an autosomal recessive condition with onset between ages 2 and 4 years, when painful circumscribed calluses develop on the pressure points of the palm of the hand and sole of the foot.