Triple response of Lewis
![Evolution of inflammatory processes in the three points described by Lewis.](/Images/godic/202502/17/Rispostadilewis3307.jpg")
The triple response of Lewis is a cutaneous response that occurs from firm stroking of the skin, which produces an initial red line, followed by a flare around that line, and then finally a wheal.
The triple response of Lewis is due to the release of histamine.