Triple-A syndrome

Triple-A syndrome (AAA), also known as Achalasia-Addisonianism-Alacrima syndrome or Allgrove syndrome, is a rare autosomal recessive congenital disorder. In most cases, there is no family history of it. The syndrome was discovered by Jeremy Allgrove and colleagues in 1978. Triple A stands for achalasia-addisonianism-alacrima syndrome. Alacrima is usually the earliest manifestation. It is a progressive disorder that can take years to develop the full blown clinical picture.