Alfedena is a comune in the province of L'Aquila of the Abruzzo region of central Italy. It is located in the Abruzzo, Lazio and Molise National Park in the upper Sangro valley, near the Monti della Meta mountain chain.

Alfedena, as we know it today, was founded by the Samnites, who called it Aufidena, because of its excellent strategic view over the high Sangro valley. Alfedena was the setting of several conflicts through its history because of this location. Alfedena was a district of the superior Samnites before it was the capital town of the Carecini tribe during their first settlement near the high Saro, the ancient name of today’s Sangro river. Alfedena was then conquered by the Romans in 298 b.c., and by the Longobards during the 11th century.