烟草天蛾（学名：Manduca sexta），又名传粉夜蛾，是天蛾科的一种蛾，在美洲大陆大部分地区可见。它很容易与番茄天蛾（Manduca quinquemaculata）混淆。两者长相相似，且属于同一属。其幼虫都以茄科植物的叶子为食。烟草天蛾两侧有7对斜线，番茄天蛾则有8个V形图案。 烟草天蛾身体有一种机制，选择性地吸收和分泌烟草中的神经毒素尼古丁。

烟草天蛾是一种常见的模式生物，特别在神经生物学，这是由于它神经系统很容易获得并且其生命周期较短。它是用于各种生物医学和生物科学实验。它可以很容易用小麦胚芽为主的食物饲养。幼虫比较大，因而比较容易解剖和分离器官。

Manduca sexta is a moth of the family Sphingidae present through much of the American continent. Commonly known as the Carolina sphinx moth (as adults) and the tobacco hornworm and the goliath worm (as larvae), it is closely related to and often confused with the very similar tomato hornworm (Manduca quinquemaculata); the larvae of both feed on the foliage of various plants of the family Solanaceae. The tobacco hornworm is sometimes kept as a pet by children throughout its range. The larvae of these species can be distinguished by their lateral markings: Tomato hornworms have eight V-shaped white markings with no borders; tobacco hornworms have seven white diagonal lines with a black border. Additionally, tobacco hornworms have red horns, while tomato hornworms have dark blue or black horns. A mnemonic to remember the markings is tobacco hornworms have straight white lines like cigarettes, while tomato hornworms have V-shaped markings (as in "vine-ripened" tomatoes). M. sexta has mechanisms for selectively sequestering and secreting the neurotoxin nicotine present in tobacco.