A third factor is damage to the endothelial cell lining of a blood vessel which exposes tissue factor and collagen.
第三个因素是血管壁的损伤,这使得组织因子和胶原得以暴露。
Osmosis-血液肿瘤
The first way is called the extrinsic pathway, which starts when tissue factor gets exposed by the injury of the endothelium.
第一种是外源性凝血途径由组织因子暴露于血管壁损伤处后启动。
Osmosis-血液肿瘤
Procoagulants could be proteins like tissue factor or bacterial components like lipopolysaccharide, or could even be the presence of enzymes that help to proteolytically cleave and activate clotting factors.
Tissue factor turns inactive factor VII into activate factor VIIa (a for active), and then tissue factor goes on to bind the newly formed factor VIIa to form a complex that turns factor X into active factor Xa.
After that, some platelets adhere to the damaged vessel wall, and become activated by collagen and tissue factor, proteins which are normally kept separated from the blood by an intact endothelium.
接着,血小板粘附至损伤的血管壁,并且被胶原和组织因子活化;这些蛋白质平常由完好的血管壁与血液隔离。
英语百科
Tissue factor
Tissue factor, also called platelet tissue factor, factor III, thromboplastin, or CD142 is a protein present in subendothelial tissue and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X - the tissue factor pathway. In doing so it has replaced the previously named extrinsic pathway in order to eliminate ambiguity.