Teplizumab

Teplizumab (also known as MGA031 and hOKT3γ1(Ala-Ala)) is a humanized monoclonal antibody that is used as an immunosuppressive drug. The Fc region of this antibody has been engineered to have Fc receptor non-binding (FNB) properties. Teplizumab was originally developed at Columbia University, and was then further developed at MacroGenics, Inc.