Tolcapone


![Rat Catechol-O-methyltransferase bound to Tolcapone. PDB entry 3s68[2]](/Images/godic/202502/15/3s68_tcw5829.png")

Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitro catechol type inhibitor of enzyme catechol-O-methyl transferase (COMT).
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