硫酰基尿素类（英语：Sulfonylurea）衍生物是用于2型糖尿病的抗糖尿病药。主要作用是促进胰脏β细胞分泌胰岛素。

硫酰基尿素类是由法国科学家Marcel Janbon和他的同事们发现的，当他们在研究磺酰胺抗生素时，发现硫酰基尿素会使动物们产生低血糖的反应。

Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture. They are antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas. A number of sulfonylureas are also used as herbicides ("weedkiller"), because they can interfere with plant biosynthesis of certain amino acids.