圣卢西亚县（Saint Lucie County, Florida）是美国佛罗里达州东部的一个县，东傍大西洋。面积1,782平方公里。根据美国2000年人口普查，共有人口192,695。县治匹尔斯堡 （Port Pierce）。

1905年5月24日自布拉瓦县分出（该县原名同为圣卢西亚县，1855年改名）。县名纪念天主教与东正教殉道圣人圣路济亚。

St. Lucie County is a county located in the state of Florida, in the United States. As of the 2010 census, the population was 277,789. The county seat is Fort Pierce. As of the 2015 Census Estimate, St. Lucie County is at a population of 298,563.

St. Lucie County is included in the Port St. Lucie, FL Metropolitan Statistical Area, which is also included in the Miami-Fort Lauderdale-Port St. Lucie, FL Combined Statistical Area.