Squinzano is a town and comune of 14,308 inhabitans (2015) in the province of Lecce in the Apulia region of south-east Italy. It is the twelfth most populous city in the province of Lecce.

Squinzano is also a specific area within the Apulian wine region. Squinzano DOC is produced in red and rosé versions, and is obtained principally from the Negro Amaro grape, with a small addition of Malvasia Nera di Brindisi and Malvasia Nera di Lecce.