Spadafora (Sicilian: Spatafora) is a comune (municipality) in the Province of Messina in the Italian region Sicily, located about 180 kilometres (110mi) east of Palermo and about 15 kilometres (9mi) northwest of Messina. As of 31 December 2004, it had a population of 5,322 and an area of 10.3 square kilometres (4.0sqmi).