Sophron of Syracuse (fl. 430 BC) was a writer of mimes.

Sophron was the author of prose dialogues in the Doric dialect, containing both male and female characters, some serious, others humorous in style, and depicting scenes from the daily life of the Sicilian Greeks. Although in prose, they were regarded as poems; in any case they were not intended for stage representation. They were written in pithy and popular language, full of proverbs and colloquialisms.