Solid phase extraction
![A typical solid phase extraction manifold. The cartridges drip into the chamber below, where tubes collect the effluent. A vacuum port with gauge is used to control the vacuum applied to the chamber.](/Images/godic/202502/12/SPE_Manifold2225.jpg")
![A selection of solid phase extraction cartridges, available in many sizes, shapes, and types of stationary phase.](/Images/godic/202502/12/SPE_Cartridges2225.jpg")
Solid-phase extraction (SPE) is a sample preparation process by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the mixture according to their physical and chemical properties. Analytical laboratories use solid phase extraction to concentrate and purify samples for analysis. Solid phase extraction can be used to isolate analytes of interest from a wide variety of matrices, including urine, blood, water, beverages, soil, and animal tissue.