Finally, with protein C or S deficiency, there can be warfarin induced skin necrosis, which means tiny thrombi can form in the blood vessels of the skin, causing skin necrosis.

此外，患者身上还可能出现华法林导致的皮肤坏死，也就是说在皮肤血管中形成小血栓，导致皮肤坏死。

A more serious presentation is neonatal purpura fulminans, which is when a newborn with protein C or S deficiency suffers massive arterial and venous thromboembolisms with hemorrhagic skin necrosis.

更严重的并发症是新生儿暴发性紫癜，即患有蛋白C和S缺乏症的新生儿出现大量动静脉血栓栓塞及出血性皮肤坏死。