The Skellefte River (Swedish: Skellefteälven or Skellefte älv) is a river in northern Sweden; one of the major Norrland rivers..

Geographically, it starts in the Norrbotten County, also known as the Swedish Lappland province where it drains the lakes Hornavan, Uddjaur and Storavan near Arjeplog; then goes south-east into Västerbotten County, passing through the town Skellefteå (which has given it its name), and finally discharging in the Gulf of Bothnia, in the Västerbotten province.