After many signal successes, and equally signal losses, they at last lost Madras, at that time their principal settlement in India.

在多次取得成功和同样的失败之后，他们终于失去了马德拉斯，当时他们在印度的主要定居点。

Since usually there's this balance of signaling between dopamine and acetylcholine, a loss of dopamine reaching the striatum increases the relative amount of acetylcholine signalling there.

由于多巴胺和乙酰胆碱之间有一种平衡，多巴胺减少的信号传到纹状体，导致乙酰胆碱信号发出相应增加。