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词汇 serpin
分类 英语词汇 英语翻译词典
释义

serpin

英汉-汉英词典
丝氨酸蛋白酶抑制蛋白
词组 | 习惯用语
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  • scorpion n. 蝎子；蝎尾鞭；心黑的人
  • serpent n. 蛇（尤指大蛇或毒蛇）；狡猾的人
  • reserpine n. 血压平；降血压；[药学]利血平；蛇根碱
  • serpentine adj. 像蛇般蜷曲的,蜿蜒的
serpins 丝氨酸蛋白酶抑制剂
serpin 丝氨酸蛋白酶抑制剂; n. (Serpin)人名；(法)塞尔潘;

网络短语:
Serpins 舍平类; 丝氨酸蛋白酶抑制剂; 属于丝氨酸蛋白酶抑制剂;
mammary serpin 丝氨酸蛋白酶抑制剂
serpin superfamily 丝氨酸蛋白酶抑制剂超家族
Anti-SERPIN A11 丝氨酸蛋白酶抑制剂A11抗体
原声例句
Osmosis-呼吸

The gene that encodes alpha-1 antitrypsin protein is called SERPINA1, which stands for serpin peptidase inhibitor, clade A, member 1.

编码α-1抗胰蛋白酶的基因是SERPINA1，代表丝氨酸蛋白酶抑制剂，A系，1成员。

中文百科

丝氨酸蛋白酶抑制剂

A protease (grey) bound to a serpin reactive centre loop (RCL, blue). When the protease's catalytic triad (red) cleaves the RCL, it becomes trapped in an inactive conformation. (PDB: 1K9O​)
The native state of serpins is an equilibrium between a fully stressed state (left) and a partially relaxed state (right). The five-stranded A-sheet (light blue) contains two functionally important regions for the serpin's mechanism, the breach and the shutter. The reactive centre loop (RCL, blue) exists in a dynamic equilibrium between the fully exposed conformation (left) and a conformation where it is partially inserted into the breach of the A-sheet (right).(PDB: 1QLP, 1YXA​)[42][43]
The inhibitory mechanism of serpins involves a large conformational change (S to R transition). The serpin (white) first binds a protease (grey) with the exposed reactive centre loop (blue). When this loop is cleaved by the protease, it rapidly inserts into the A-sheet (light blue), deforming and inhibiting the protease. (PDB: 1K9O, 1EZX​)Serine and cysteine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the cysteine or serine of the catalytic triad (red) to form an acyl-enzyme intermediate. For typical substrates, the intermediate is resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX​)

丝氨酸蛋白酶抑制剂（英语：serpin）是具有相似结构蛋白质的蛋白质超家族，它是由于蛋白酶抑制活性被识别的，和在生命的各个界被发现的第一个蛋白质超家族。英文缩写丝氨酸蛋白酶抑制剂（英语：serpin）最初被创造，是因为第一个丝氨酸蛋白酶抑制剂对胰凝乳蛋白酶样丝氨酸蛋白酶（丝氨酸蛋白酶抑制剂）将要被识别的行为。
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