瑟纳费是非洲东北部国家厄立特里亚的城镇，由南部区负责管辖，位于该国南部埃塞俄比亚高地边缘，海拔高度2,434米，2010年人口估计约7,440。

Senafe (Tigrinya:ሰንዓፈ Tigrinya pronunciation: [sɐnʕafɐ]) is a market town in southern Eritrea, on the edge of the Eritrean highlands. The surrounding area is inhabited by the Saho people and the Tigrinya people.

Senafe is known for the ruins of Metera (also known as Balaw Kalaw), the monolithic church of Enda-Tradqan and for the local stone outcrops.