Adenylylsulfatase

In enzymology, an adenylylsulfatase (EC3.6.2.1) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are adenylyl sulfate and H₂O, whereas its two products are AMP and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is adenylyl-sulfate sulfohydrolase. Other names in common use include adenosine 5-phosphosulfate sulfohydrolase, and adenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism.