羊搔痒症（英语：Scrapie），是一种退化性疾病，发生在绵羊及山羊上，造成它们的神经系统异常。它跟牛海绵状脑病与鹿的慢性消耗病相同，都是传染性海绵状脑病的一种，由异常的普利昂蛋白所引起。它在1732年于英国的牧场发现，目前没有传染至人体的病例。

羊搔痒症的名称来自于它在诊断上特别的病征，受到感染的羊，会不停的摩擦石头、树或篱笆来抓痒。

Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one of several transmissible spongiform encephalopathies (TSEs), which are related to bovine spongiform encephalopathy (BSE or "mad cow disease") and chronic wasting disease of deer. Like other spongiform encephalopathies, scrapie is caused by a prion. Scrapie has been known since 1732, and does not appear to be transmissible to humans.