圣弗朗西斯科德马科里斯是中美洲国家多米尼加共和国的城市，也是杜华德省的首府，位于该国北部，始建于1778年，面积727.15平方公里，海拔高度110米，2012年人口245,397。

San Francisco de Macorís is a city in the Dominican Republic located in the northeast portion of the island, in the Cibao region. It is the capital of the Duarte Province, and the sixth most populated city in the country. The name San Francisco de Macorís comes from a fusion of the name of Saint Francis, patron saint of the Franciscan Order (a religious organization from Italy that had come to this territory during colonization) and the territory's old name, which is Macorix.