Rottofreno is a comune (municipality) in the Province of Piacenza in the Italian region Emilia-Romagna, located about 160 kilometres (99mi) northwest of Bologna and about 12 kilometres (7mi) west of Piacenza.
Rottofreno borders the following municipalities: Borgonovo Val Tidone, Calendasco, Chignolo Po, Gragnano Trebbiense, Monticelli Pavese, Piacenza, and Sarmato.