Ribonuclease L
（重定向自RNAse L）
![](/Images/godic/202502/07/Protein_RNASEL_PDB_1wdy4036.png")
![](/Images/godic/202502/07/PBB_GE_RNASEL_221287_at_tn4036.png")
![RNase L activation pathway-IFN factors bind the receptor and lead transcription and modifications of OAS. Viral dsRNA binds OAS, so that 2'-5'A is produced leading to the dimerization of RNase L. Activated RNase L cleaves all RNA in the cell, which can activate MDA5 leading to interferon production.](/Images/godic/202502/07/RNAse_L_Pathway_new4036.png")
![](/Images/godic/202502/07/PDB_1wdy_EBI4036.jpg")
Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease — is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene.