When the defect is large, a clinically significant left-to-right blood flow may overload the right side of the heart, resulting in its enlargement and eventually right side heart failure.

当缺损很大时，临床上显著的从左到右的血流可能会使心脏右侧超负荷，导致心脏右侧增大，最终导致右心衰竭。