Rhodotorulic acid

Rhodotorulic acid is the smallest of the 2,5-diketopiperazine family of hydroxamate siderophores which are high-affinity chelating agents for ferric iron, produced by bacterial and fungal phytopathogens for scavenging iron from the environment. It is a tetradentate ligand, meaning it binds one iron atom in four locations (two hydroxamate and two ketone moieties), and forms Fe₂(siderophore)₃ complexes to fulfill an octahedral coordination for iron. Rhodotorulic acid occurs in basidiomycetous yeasts and was found to retard the spore germination of the fungus Botrytis cinerea. In combination with yeast R. glutinis it was found to be effective in the biocontrol of iprodione-resistant B. cinerea of apple wounds caused by the disease.