As before, the excess cortisol provides negative feedback to the hypothalamus and pituitary gland, suppressing CRH and ACTH production.

像之前一样，过多的皮质醇会导致下丘脑和脑下垂体的负反馈，抑制CRH和ACTH的产生。

Unlike pituitary adenomas, ectopic sites of ACTH productions typically don't respond even to high doses of dexamethasone, and the serum cortisol remains high.

和垂体腺瘤不同，异位ACTH综合征一般对高剂量地塞米松没有反应，血清皮质醇还是会很高。

Low ACTH levels can be seen in adrenal adenomas and carcinomas, whereas high ACTH levels can be seen in Cushing disease and ectopic ACTH production.

肾上腺腺瘤和肾上腺癌会检测出低水平ACTH，库欣病和异位ACTH综合征会检测出高水平ACTH。

Alternatively, medications such as adrenal steroid inhibitors, like ketoconazole and metyrapone can be helpful - especially for cases of ectopic ACTH production or adrenal carcinomas that have already spread.

另一种方法，像肾上腺类固醇生成抑制剂药物，比如酮康唑和甲吡酮，也会有帮助，尤其是在异位ACTH综合征或已经扩散的肾上腺癌中。

Another option is also the dexamethasone suppression test, which is when a person is given a low dose of dexamethasone, which is an exogenous steroid that suppresses ACTH production in the pituitary gland.

另一种方法是地塞米松抑制试验，给被试低剂量的地塞米松，一种外源性类固醇，抑制垂体生成ACTH。