Renin inhibitor

Renin–angiotensin–aldosterone system and potential steps of blockage

Remikiren, a second-generation renin inhibitor

Renin inhibitors are a group of pharmaceutical drugs used primarily in treatment of essential hypertension (high blood pressure).

These drugs inhibit the first and rate-limiting step of the renin–angiotensin–aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I.This leads to a totality in absence of Angiotensin II based on the rationale that renin only acts to inhibit this step unlike Angiotensin Converting Enzyme which is also involved in other biochemical reactions. Since the 1970s, scientists have been trying to develop potent inhibitors with acceptable oral bioavailability. The process was difficult and took about three decades. The first and second generations faced problems such as poor bioavailability and lack of potency. Finally, the third generation was discovered. These compounds were nonpeptidic renin inhibitors, had acceptable oral bioavailability and were potent enough for clinical use. The first drug in this class was aliskiren, which received a marketing approval in 2007. As of January 2012, it is the only renin inhibitor on the market.

词汇	Renin inhibitor
分类	英语词汇英语翻译词典
释义	Renin inhibitor 原声例句 Osmosis-泌尿 Along the same lines, drugs that reduce the effect of aldosterone can also cause hyperkalemia, and these are drugs like renin inhibitors, ACE inhibitors, angiotensin II receptor antagonists, selective aldosterone blockers, and potassium-sparing diuretics. 同理，可以降低醛固酮效能的药物也可以导致高钾血症，例如肾素抑制剂、ACE抑制剂、血管紧张素II受体拮抗剂、选择性醛固酮受体阻滞剂以及保钾利尿剂等。英语百科 Renin inhibitor Renin inhibitors are a group of pharmaceutical drugs used primarily in treatment of essential hypertension (high blood pressure). These drugs inhibit the first and rate-limiting step of the renin–angiotensin–aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I.This leads to a totality in absence of Angiotensin II based on the rationale that renin only acts to inhibit this step unlike Angiotensin Converting Enzyme which is also involved in other biochemical reactions. Since the 1970s, scientists have been trying to develop potent inhibitors with acceptable oral bioavailability. The process was difficult and took about three decades. The first and second generations faced problems such as poor bioavailability and lack of potency. Finally, the third generation was discovered. These compounds were nonpeptidic renin inhibitors, had acceptable oral bioavailability and were potent enough for clinical use. The first drug in this class was aliskiren, which received a marketing approval in 2007. As of January 2012, it is the only renin inhibitor on the market.
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