阿克里河（西班牙语：Río Acre，葡萄牙语：Rio Acre）是南美洲中部的河流，河道全长650公里（400英哩），从发源地秘鲁流向东北方向，成为玻利维亚和巴西接壤的部分边境，流经巴西的阿克里州和亚马孙州后流入普鲁斯河。阿克里河的可航行河道长480公里（300英哩），是19世纪末的运输要道。

The Acre River (called Aquiry in the local Iñapari language; locally, Rio Acre) is a 680 kilometres (420 mi) long river in central South America. The river is born in Peru, and runs North-Eastwards, forming part of the border between Bolivia and Brazil. It runs through the Brazilian states of Acre and Amazonas before eventually running into the Purus River at Boca do Acre. It boards on the Bolivian frontier and flows Easter and North to a junction with the Purus at 8° 45' South latitude. The name is also applied to a district situated on the same river and on the former boundary line of 1867, between Bolivia and Brazil. This region's area is estimated at about 60,000 square miles (160,000 km).