In 1921, while working for the General Motors Research Corporation in Dayton, Ohio, he investigated a compound called tetraethyl lead (also known, confusingly, as lead tetraethyl), and discovered that it significantly reduced the juddering condition known as engine knock.

1921年，他在位于俄亥俄州代顿的通用汽车研究公司工作期间，对一种名叫四乙铅的化合物作了研究，发现它能大大减少震动现象，即所谓的发动机爆震。