乙酰溴（化学式：CH₃C(O)Br），是由乙酸衍生出的酰溴。

无色发烟液体。在空气中渐变黄，遇水或乙醇激烈反应。能与乙醚、苯、氯仿混溶。易燃。有刺激性。

Acetyl bromide is an acyl bromide compound. As is expected, it may be prepared by reaction between phosphorus tribromide and acetic acid:

As usual for an acid halide, acetyl bromide hydrolyzes rapidly in water, forming acetic acid and hydrobromic acid. It also reacts with alcohols and amines to produce acetate esters and acetamides, respectively.