库斯科（西班牙文：Cuzco），又译作科斯科（盖丘亚语：Qosqo；发音[ˈqo̝s.qo]），是秘鲁东南方的城市，人口约有30万人，座落在Huatanay谷中（Huatanay有神圣的意思），被安地斯山脉环绕，是古老的印加帝国的摇篮。库斯科是库斯科大区及库斯科省的首府。

库斯科是一个高海拔城市，海拔有3400公尺（11024英尺），它的名字在秘鲁当地话中（盖丘亚语）意味着「肚脐」。1983年，城市中的古城列入联合国教科文组织世界遗产，登录名称为科斯科古城。

Cusco (/ˈkuːzkoʊ/), often spelled Cuzco (Spanish:Cuzco, [ˈkusko]; Quechua:Qusqu or Qosqo, IPA: [ˈqɔsqɔ]), is a city in southeastern Peru, near the Urubamba Valley of the Andes mountain range. It is the capital of the Cusco Region as well as the Cusco Province. In 2013, the city had a population of 435,114. Located on the eastern end of the Knot of Cuzco, its elevation is around 3,400 m (11,200 ft).