Pyruvate dehydrogenase
（重定向自Pyruvate oxidation）
![](/Images/godic/202502/05/PDwhole10137.jpg")
![Regulation of Pyruvate Dehydrogenase](/Images/godic/202502/05/1400x1048_pdh_regulation0138.png")
![](/Images/godic/202502/05/PyruvateDehydrgenaseMech10138.gif")
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Pyruvate dehydrogenase is the first component enzyme of pyruvate dehydrogenase complex (PDC). The pyruvate dehydrogenase complex contributes to transforming pyruvate into acetyl-CoA by a process called pyruvate decarboxylation (Swanson Conversion). Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, so pyruvate dehydrogenase contributes to linking the glycolysis metabolic pathway to the citric acid cycle and releasing energy via NADH.