Catechol 1,2-dioxygenase
![](/Images/godic/202502/05/Structure_of_Catechol_1,2-dioxygenase_from_Acinetobacter_Calcoaceticus_Native_Data2439.jpg")
![Figure 1. The overall reaction of catechol 1,2-dioxygenase. Using a non-heme iron(III) complex, 1,2-CTD is able to oxidatively cleave catechol into cis,cis-muconic acid.](/Images/godic/202502/05/Overall_Catechol_1,2-dioxygenase_Reaction_Mechanism2439.jpg")
![Figure 2. The active site of 1,2-CTD. This non-heme Fe3+ complex is axially ligated by Tyr200 and His226 and equatorially ligated by Tyr164, His224, and a solvent water molecule, giving the active site an overall trigonal bipyramidal geometry](/Images/godic/202502/05/Catechol_1,2-dioxygenase2439.jpg")
![Figure 3. The mechanism by which 1,2-CTD utilizes a non-heme Fe3+ complex to oxidatively cleave catechol to form cis,cis-muconic acid.](/Images/godic/202502/05/Catechol_1,2-dioxygenase_Mechanism2440.jpg")
Catechol 1,2- dioxygenase (EC1.13.11.1, 1,2-CTD, catechol-oxygen 1,2-oxidoreductase, 1,2-pyrocatechase, catechase, catechol 1,2-oxygenase, catechol dioxygenase, pyrocatechase, pyrocatechol 1,2-dioxygenase, CD I, CD II) is an enzyme that catalyzes the oxidative ring cleavage of catechol to form cis,cis-muconic acid: