In the related "amide route" starting from 2-chloroisonicotinic acid, 41 ,a secondary amide directing group was used to facilitate the ortho lithiation of the pyridine 3-position. 在有关"酰胺三号"由2-氯酸、41、次要酰胺导演组用的锂方便邻吡啶3-立场.
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH-) replaced by a nitrogen atom. The pyridine ring occurs in many important compounds, including azines and the vitamins niacin and pyridoxal.