吡嗪酰胺（Pyrazinamide）是一种治疗结核病的药物，有抗菌杀菌的功效，在pH值较低（5～5.5）的条件下，抗菌活性最强。其主要的副作用是可能引起血液中尿酸增高，从而引发关节痛。

Pyrazinamide is a drug used to treat tuberculosis. The drug is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria.

It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.