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词汇 Proteolytic cleavage
分类 英语词汇 英语翻译词典
释义

Proteolytic cleavage

中文百科

蛋白酶 Protease

（重定向自Proteolytic cleavage）
蛋白酶的所催化的反应
TEV蛋白酶的结构，其中红色的为催化三联体
Figura 1. Mecanismo de acción de las diferentes clases de proteasas
A comparison of the two hydrolytic mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism.

蛋白酶（英语：protease）是生物体内的一类酶（酵素），它们能够分解蛋白质。分解方法是打断那些将氨基酸链接成多肽链的肽键。

抑制蛋白酶活性的小分子化合物被称蛋白酶抑制剂。许多病毒蛋白酶的抑制剂是很有效的抗病毒药。

英语百科

Protease 蛋白酶

（重定向自Proteolytic cleavage）
The structure of a protease (TEV protease) complexed with its peptide substrate in black with catalytic residues in red. (PDB: 1LVB​)
A comparison of the two hydrolytic mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism.
蛋白酶的所催化的反应
Figura 1. Mecanismo de acción de las diferentes clases de proteasas

A protease (also called a peptidase or proteinase) is any enzyme that performs proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in a polypeptide chain. Proteases have evolved multiple times, and different classes of protease can perform the same reaction by completely different catalytic mechanisms. Proteases can be found in animals, plants, bacteria, archaea and viruses.
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