前列腺素E₂，亦称地诺前列酮，是前列腺素的一种，发现于1976年。主要用于分娩时软化子宫颈、引发子宫收缩，此外也可以用作堕胎药、刺激造骨细胞。

The naturally occurring prostaglandin E2 (PGE2 or PGE₂) is known in medicine as dinoprostone. It has important effects in labour (softening the cervix and causing uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever.