前胶原肽酶（英语：Procollagen peptidase，EC3.4.24.14，也被称为“前胶原N-端肽酶”procollagen N-terminal peptidase，“前胶原氨基肽酶”procollagen aminopeptidase，“氨基前胶原肽酶”aminoprocollagen peptidase，“氨基末端前胶原肽酶”aminoterminal procollagen peptidase，“前胶原氨基末端肽酶”procollagen aminoterminal protease，“前胶原N-端蛋白酶”procollagen N-terminal proteinase，“I型/II型前胶原N-蛋白酶”type I/II procollagen N-proteinase，“III型前胶原”type III procollagen）是一种与胶原蛋白相关的内肽酶。此酶用于切除前胶原肽的N末端串行，缺失此酶会导致皮肤脆裂症或埃勒斯-当洛二氏症候群。

Procollagen peptidase (EC3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.