Disulfiram

Disulfiram (sold under the trade names Antabuse and Antabus) is a drug discovered in the 1920s that is used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means many of the effects of a "hangover" are felt immediately after alcohol is consumed.