According to the earlier mentioned book, 90 out of 91 clinical trials found that opioid antagonists like Naltrexone are effective if extinction is possible, that is if a substance-addicted person can use the opioid antagonist medication and use the substance.
An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors.
Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors. This effectively blocks the receptor, preventing the body from responding to opioids and endorphins.