奥珀卢萨斯（Opelousas, Louisiana)，美国路易斯安那州圣兰德县县治，位于49号州际公路与190号国道交汇处。2000年美国人口普查为22,860人口。

奥珀卢萨斯创建于1720年，是路易斯安那州第三古老的城市。该市因美国印第安人部落Appalousa而得名。

Opelousas is also a common name of the flathead catfish.

Opelousas (French: Les Opelousas) is a city in and the parish seat of St. Landry Parish, Louisiana, United States. It lies at the junction of Interstate 49 and U.S. Route 190. The population was 22,860 at the 2000 census. Although the 2006 population estimate was 23,222, a 2004 annexation should put the city's population above 25,000. In the 2010 census, the population shrunk to 16,634. Opelousas is the principal city for the Opelousas-Eunice Micropolitan Statistical Area, which had an estimated population of 92,178 in 2008. Opelousas is also the 3rd largest city in the Lafayette-Acadiana Combined Statistical Area, which has a population of 537,947.