Ogbomosho (also Ogbomoṣo) is a city in Oyo State, south-western Nigeria, on the A1 highway. It was founded in the mid 17th century. The population was approximately 645,000 in 1991; by March 2005, it was estimated at around 1,200,000.

The City is considered one of Nigeria's largest urban centers. The majority of the people are members of the Yoruba ethnic group. Yams, cassava, maize, and tobacco are some of the notable agricultural products of the region.