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词汇 Nucleotide excision repair
分类 英语词汇 英语翻译词典
释义

Nucleotide excision repair

中文百科

核苷酸切除修复

核苷酸切除修复是一种DNA修复方法。由于化学、辐射和很多其他因素的都会对DNA碱基对造成破坏，DNA时常需要修复。核苷酸切除修复是其中一种很重要的方法，通过移除绝大部分紫外线导致的DNA损伤，使得细胞免于受到有害变异的影响（主要形式为胸腺嘧啶二聚体及6,4-光产物）。其发现者，瑞典生物化学家托马斯·林达尔凭此获得2015年诺贝尔化学奖。

英语百科

Nucleotide excision repair 核苷酸切除修复

Diagram of both the TC-NER and GG-NER pathways. The two pathways differ only in initial DNA damage recognition.[1]
Schematic depicts binding of proteins involved with GG-NER.[3]
Schematic depicts binding of proteins involved with TC-NER.[3]
A schematic representation of models for the nucleotide excision repair pathway controlled by Uvr proteins.[4]

Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs.
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