Nacolomab tafenatox
![Schematic image of nacolomab tafenatox.
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)](/Images/godic/202501/28/Fab-superantigen-fusion_protein.svg0745.png")
Nacolomab tafenatox is a mouse monoclonal antibody designed for the treatment of colorectal cancer. The antibody itself, nacolomab, is fused with enterotoxin A from Staphylococcus aureus (which is reflected by 'tafenatox' in the drug's name).