Myc

Overview of signal transduction pathways involved in apoptosis.

Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation, and results in the formation of cancer. A common human translocation involving Myc is critical to the development of most cases of Burkitt Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung and stomach. Myc is thus viewed as a promising target for anti-cancer drugs.

词汇	Myc
分类	英语词汇英语翻译词典
释义	Myc 原声例句 Osmosis-血液肿瘤 The Myc gene stimulates cell growth and metabolism, so the translocation results in increased cell division. MYC基因刺激细胞生长和新陈代谢，因此，易位导致细胞分裂加速。 Osmosis-血液肿瘤 In this case, the Myc gene is translocated from chromosome 8 where it ends up adjacent to IgH promoter on chromosome 14 and again that upregulates its expression. 在这种情况下，MYC基因从8号染色体易位至14号染色体，最终与14号染色体上的IgH启动子相邻，这也上调了它的表达。英语百科 Myc Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation, and results in the formation of cancer. A common human translocation involving Myc is critical to the development of most cases of Burkitt Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung and stomach. Myc is thus viewed as a promising target for anti-cancer drugs.
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