莫塔瓜河是危地马拉的河流，河道全长486公里，流域面积12,670平方公里，发源自该国西部高地，成为该国与洪都拉斯接壤的边境，最终注入洪都拉斯湾。

• Map of Guatemala including the river
• Jade sources in The Motagua River Valley

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The Motagua River (Spanish pronunciation: [moˈtaɣwa]) is a 486-kilometre (302 mi) long river in Guatemala. It rises in the western highlands of Guatemala where it is also called Río Grande, and runs in an easterly direction to the Gulf of Honduras. The final few kilometres of the river form part of the Guatemala/Honduras border. The Motagua River basin covers an area of 12,670 square kilometres (4,890 sq mi) and is the largest in Guatemala.