Microcarrier

A microcarrier is a support matrix allowing for the growth of adherent cells in bioreactors.

In 1967, microcarrier development began when van Wezel found that microcarriers could support the growth of anchorage-dependent cells. Microcarriers are typically 125 - 250 micrometre spheres and their density allows them to be maintained in suspension with gentle stirring. Microcarriers can be made from a number of different materials including DEAE-dextran, glass, polystyrene plastic, acrylamide, collagen, and alginate. These microcarrier materials, along with different surface chemistries, can influence cellular behavior, including morphology and proliferation. Surface chemistries can include extracellular matrix proteins, recombinant proteins, peptides, and positively or negatively charged molecules.