Vinculin
（重定向自Metavinculin）
![](/Images/godic/202501/27/Protein_VCL_PDB_1qkr5653.png")
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![](/Images/godic/202501/27/PBB_GE_VCL_200930_s_at_tn5654.png")
![](/Images/godic/202501/27/PDB_1rkc_EBI5654.jpg")
In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.